Paul Jardine, BSc, DUT, PhD

Dr. Jardine’s primary appointment is as a Professor in the School of Dentistry, where he studies virus structure and assembly and teaches microbiology. He has been involved in both interdisciplinary teaching and research throughout his career. He earned a Diploma in University Teaching from the University of New Brunswick, Canada, where he acted as a facilitator in graduate level interdisciplinary courses in science philosophy and research design. At the University of Minnesota School of Dentistry, he has been a facilitator in professional ethics courses, as well as the course pilots of FIPCC. As part of his research efforts studying biological molecular motors, he is part of a broad, interdisciplinary research team that brings together the fields of virology, biochemistry, genetics, structural biology, and biophysics.

Virus structure and assembly; Biochemistry, Biophysics and Structural Biology; Interprofessional Education

My interests revolve around the investigation of viral assembly and the description of biological motors at the molecular level. Both historically and experimentally, bacteriophages provide a perfect system to address both of these issues. My current focus is on the study of bacteriophage phi29 DNA packaging. A molecular motor assembles transiently to the phi29 prohead capsid and packages DNA to near crystalline density, powered by ATP hydrolysis. To fully describe the mechanism of this motor, and gain understanding about molecular motors in general, I am part of a large interdisciplinary group comprised of specialists in structural biology, biophysics, molecular genetics and biochemistry. As a phage biochemist, my role is to translate the basic components of phi29 packaging from our robust in vitro packaging system into hands of specialist who can address the questions of interest our work has generated, as well as develop new approaches meant to interrogate the packaging mechanism.

Academic Interests and Focus: Virology; Biochemistry
 

Diploma in University Teaching, Visiting Engagement
University of New Brunswick Teaching Centre
Canada

Award: The DNA Packaging Motor of Bacteriophage phi29
Principal Investigator: Jardine, Paul James
Sponsoring Organization: NIH NIGMS NATL INST OF GENERAL
Award Dates: 2021 - 2025

Award: Mechanisms of Viral DNA Packaging - UCBerkeley - Resubmi
Principal Investigator: Jardine, Paul James
Sponsoring Organization: UNIVERSITY OF CALIFORNIA, BERKELEY
Award Dates: 2018 - 2019

Award: The DNA Packaging Motor of Bacteriophage phi29
Principal Investigator: Jardine, Paul James
Sponsoring Organization: NIH NIGMS NATL INST OF GENERAL
Award Dates: 2017 - 2021

Award: Collaborative Research: Physical parameters controlling
Principal Investigator: Jardine, Paul James
Sponsoring Organization: THE NATIONAL SCIENCE FOUNDATION
Award Dates: 2017 - 2022

Award: The DNA Packaging Motor of Bacteriophage phi29
Principal Investigator: Jardine, Paul James
Sponsoring Organization: NIH NIGMS NATL INST OF GENERAL
Award Dates: 2016 - 2017

Award: Mechanisms of Viral DNA Packaging - UCBerkeley - Yr1 Rvs
Principal Investigator: Jardine, Paul James
Sponsoring Organization: UNIVERSITY OF CALIFORNIA, BERKELEY
Award Dates: 2015 - 2016

Award: RNA in Viral DNA Packaging
Principal Investigator: Jardine, Paul James
Sponsoring Organization: NIH NIGMS NATL INST OF GENERAL
Award Dates: 2014 - 2020

Award: The DNA Packaging Motor of Bacteriophage Phi29
Principal Investigator: Grimes, Shelley N
Sponsoring Organization: NIH NIGMS NATL INST OF GENERAL
Award Dates: 2011 - 2016

Award: Mechanisms of Viral DNA Packaging
Principal Investigator: Jardine, Paul James
Sponsoring Organization: UNIVERSITY OF CALIFORNIA, BERKELEY
Award Dates: 2010 - 2015

Award: Transmission Electron Microscope in the Academic Health
Principal Investigator: Zhang, Wei
Sponsoring Organization: NIH Nat'l Center for Research Resources
Award Dates: 2010 - 2012

Award: Dynamics and Energetics of Viral DNA Packaging and Eject
Principal Investigator: Jardine, Paul James
Sponsoring Organization: UNIVERSITY OF CALIFORNIA SAN DIEGO
Award Dates: 2009 - 2013

Award: Mechanisms of Viral DNA Packaging
Principal Investigator: Jardine, Paul James
Sponsoring Organization: UNIVERSITY OF CALIFORNIA, BERKELEY
Award Dates: 2004 - 2009

Award: RNA in Viral DNA Packaging
Principal Investigator: Grimes, Shelley N
Sponsoring Organization: NIH NIGMS NATL INST OF GENERAL
Award Dates: 1999 - 2014

Award: Morphogenesis of Bacteriophage phi29
Principal Investigator: Grimes, Shelley N
Sponsoring Organization: NIH NIDCR NATL INST OF DENTAL
Award Dates: 1994 - 2010