Larry Wolff, MS, PhD, DDS

Larry Wolff, MS, PhD, DDS


Office Address

17-164 Moos Tower 515 Delaware St SE
Minneapolis, MN 55455
United States

Department of Developmental and Surgical Sciences,
Division of Periodontology




DDS, University of Minnesota School of Dentistry
Major: Dentistry

PhD, Northwestern University Medical and Dental School

MA, Minnesota State University

BA, Minnesota State University

Expand all


Dr. Larry Wolff is a graduate of the University of Minnesota School of Dentistry. He received his PhD in Microbiology at Northwestern University, his DDS degree from the University of Minnesota and his certificate in Periodontics from New York University Dental Center. Dr. Wolff has been a full-time faculty member at the University of Minnesota School of Dentistry since 1980 and currently is a Professor in the Department of Developmental and Surgical Sciences. He has lectured extensively at the National and International levels in areas related to the use of antimicrobial agents as adjuncts to periodontal therapy and systemic conditions as related to periodontal disease. Dr. Wolff has numerous publications on topics surrounding the microbiology of periodontal disease and scientific investigations related to the clinical use of antimicrobials as adjuncts to periodontal treatment in dentistry and periodontics. Recently, Dr. Wolff has published extensively in the area of periodontal regeneration and tissue engineering.

Research Summary
Dr. Wolff teaches and pursues research interests in the field of periodontology. His basic research interest focuses on the bacterial etiology of periodontal diseases, new diagnostic techniques to identify bacteria in plaque, the role of cytokines on the periodontal disease process, and the expression of virulence factors by periodontopathic bacteria and the host response to those virulence factors. On the clinical side, he's currently pursuing studies of antimicrobial therapy for the treatment of periodontal disease and is also exploring the relationship between periodontal disease and a variety of systemic conditions, including cardiovascular disease and diabetes. In the area of antimicrobial therapy, Dr. Wolff studies the role of local delivery of antimicrobial therapy and systemic antibiotics as adjuncts in treating periodontal disease. Other areas of current research interest include the effect of smoking on periodontal disease and as a risk factor for progressive periodontitis, subgingival temperature as a diagnostic aid, and the effect of sonic toothbrushes in reducing plaque and gingival inflammation around implants. More recently, Dr. Wolff has pursued interest surrounding tissue regeneration and growth factors as related to regeneration of the periodontium.

Grants and Patents

Selected Grants

Award: Immunodominant Stress Proteins of Porphyromonas Gingival
Principal Investigator: Wolff, Larry Francis
Sponsoring Organization: UNIVERSITY OF MICHIGAN
Award Dates: 2009 - 2011

Award: Diabetes and Periodontics Trial
Principal Investigator: Michalowicz, Bryan S
Award Dates: 2008 - 2014

Award: A 9 Month Multicenter Clinical Trial of Treatment with P
Principal Investigator: Wolff, Larry Francis
Sponsoring Organization: Sunstar Americas, Inc.
Award Dates: 2005 - 2008