Jae Sung Lee, PhD

Dr. Jae Sung Lee is an Assistant Professor in the Department of Restorative Sciences and at the Minnesota Dental Research Center for Biomaterials and Biomechanics (MDRCBB) at the University of Minnesota School of Dentistry. He received his Ph.D. in Chemical Engineering from KAIST in South Korea. He completed postdoctoral training in Chemical Engineering and Biomedical Engineering at Purdue University, Northwestern University, and the University of Wisconsin-Madison. He worked as a Senior Scientist at Primorigen Biosciences and Dianomi Therapeutics, where he focused on commercializing his academic developments. Prior to his current role, he served as a Senior Scientist in Dr. William Murphy's group in the Department of Orthopedics and Rehabilitation at the University of Wisconsin-Madison. His research interests center around leveraging biomaterials-based approaches to address unmet scientific and clinical needs in dental and musculoskeletal tissue engineering and regenerative medicine.

Hellenbrand, D. J., Lee, J. S., Mickelson, E. J., Baer, M. C., Ott, E. L., Martinson, N. R., Celeen, M. R., Hilger, K. H., Neilsen, B. E., Jacobs, A. N., Mishra, R. R., Hurley, S. A., Murphy, W. L., Hanna, A. S. Mineral coated microparticles delivering interleukin-4, interleukin-10, and interleukin- 13 reduce inflammation and improve function after spinal cord injury in a rat. Submitted.

Fontana, G., Nemke, B., Lu, Y., Chamberlain, C., Lee, J. S., Choe, J., Jiao, H., Nelson, M., Amitrano, M., Li, W. J., Markel, M., Murphy, W. L. Local delivery of TGF-β1-mRNA supports chondrogenesis and decreases fibrosis in osteochondral defects. Submitted.

Parlato, M. B., Lee, J. S., Belair, D. G., Fontana, G., Leiferman, E., Hanna, R., Chamberlain, C., Ranheim, E. A., Murphy, W. L., Halanski, M. A. (2024). Subperiosteal delivery of transforming growth factor beta 1 and human growth hormone from mineralized PCL films. Journal of Biomedical Materials Research Part A, Online publication ahead of print.

Choe, J., Brinkman, H. M., Lee, J. S., Murphy, W. L. (2024). Optimized biomimetic minerals maintain activity of mRNA complexes after long term storage. Acta Biomaterialia, 174, 428-436. https://doi.org/10.1016/j.actbio.2023.11.044

Hellenbrand, D. J., Quinn, C. M., Piper, Z. J., Elder, R. T., Mishra, R. R., Marti, T. L., Omuro, P. M., Roddik, R. M., Lee, J. S., Murphy, W. L., Hanna, A. S. (2024). The secondary injury cascade after spinal cord injury: an analysis of local cytokine/chemokine regulation. Neural Regeneration Research, 19(6), 1308-1317. https://doi.org/10.4103/1673-5374.385849

Lee, J. S., Guo, P., Klett, K., Hall, M., Sinha, K., Ravuri, S., Huard, J., Murphy, W. L. (2022). VEGF-attenuated platelet-rich plasma improves therapeutic effect on cartilage repair. Biomaterials Science, 10(9), 2172-2181. https://doi.org/10.1039/d1bm01873f

Orth, M., Fritz, T., Stutz, J., Scheuer, C., Ganse, B., Bullinger, Y., Lee, J. S., Murphy, W. L., Laschke, M. W., Menger, M. D., Pohlemann, T. (2022). Local application of mineral-coated microparticles loaded with VEGF and BMP-2 induces the healing of murine atrophic non-unions. Frontiers in Bioengineering and Biotechnology, 9, 809397. https://doi.org/10.3389/fbioe.2021.809397

Belair, D. G., Lee, J. S., Kellner, A. V., Huard, J., Murphy, W. L. (2021). Receptor mimicking TGF-β1 binding peptide for targeting TGF-β1 signaling. Biomaterials Science, 9(3), 645-652. https://doi.org/10.1039/d0bm01374a

Hellenbrand, D. J., Haldeman, C. L., Lee, J. S., Gableman, A. G., Dai, E. K., Ortman, S. D., Gotchy, J. C., Miller, K. K., Doucas, A. M., Nowak, N. C., Murphy, W. L., Hanna, A. S. (2021). Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles. Neural Regeneration Research, 16(5), 871-877. https://doi.org/10.4103/1673-5374.297786

Fontana, G., Martin, H. L., Lee, J. S., Hematti, P., Murphy, W. L. (2019). Mineral-coated microparticles enhance mRNA-based transfection of human bone marrow cells. Molecular Therapy: Nucleic Acids, 18, 455-464. https://doi.org/10.1016/j.omtn.2019.09.004

Lee, J. S.*, Bae, S. W.*, Murphy, W. L. (2019). Dynamic, bioresponsive hydrogels via changes in DNA aptamer conformation. Macromolecular Bioscience, 19(2), 1800353. https://doi.org/10.1002/mabi.201800353 (* Equally contributed to this work)