Amy Tasca, DDS, PhD

Dr. Tasca, originally from Winona, Minnesota, completed a six-year BA/DDS program at the University of Missouri Kansas City. After graduation, she practiced general dentistry in Breckenridge, Colorado and completed a teaching fellowship in Oral Surgery at UMKC. In 2012, Dr. Tasca returned to Minnesota to begin work on her PhD in conjunction with her Certificate in Orthodontics. At the completion of her residency program, she joined the University of Minnesota’s Division of Orthodontics as a full-time faculty member.

Bone biology-Osteoclast differentiation

Clinical Cleft and Craniofacial care

Proposal: Comparison of Fixed Appliance Patients versus Clear Aligner( Invisalign) Patients for Oral Hygiene , Decalcifications and Comfort Scores
Role: Principal Investigator
Sponsoring Organization: Align
Date: September 2022

Proposal: Characterization of Mandibular Osteoclast Progenitors during Physiological and Bone Healing
Role: Co-Investigator
PI: Kim Mansky. Co-I: Elizabeth Bradley and Rachel Uppgaard
Sponsoring Organization: Osteoscience Foundation
Date: 01/01/2022-12/31/2024

Proposal: Where you originate from matters; A Comparison of Jaw and Long Bone
Osteoclast Precursors Using Single Cell Analysis
Role: Principal Investigator
Sponsoring Organization: AMERICAN ASSOCIATION OF ORTHODONTISTS FOUNDATION
Date: June 2022

NIH F32DE024679
The Role of Myosin X in BMPs Promotion of Smad1/5 in Osteoclast Formation and Function
Role: Primary Invsetigator
Sponsor: K. Mansky and R. Gopalakrishnan
Sponsoring Organization: NIH
Date: 5/2014-4/2016  

Nordeen KA, Kharouf JG, Mabry TR, Dahlke WO, Beiraghi S, Tasca AW. Radiographic Evaluation of Permanent Second Molar Substitution After Extraction of Permanent First Molar: Identifying Predictors for Spontaneous Space Closure. Pediatr Dent. 2022 Mar 15;44(2):123-130. PMID: 35484777.

Grünheid T, Tasca AW, Kanyusik JS, Walters SA, Larson BE. Assessment of orthodontic treatment efficacy of Clarity Aligners using the Peer Assessment Rating index and the American Board of Orthodontics Cast-Radiograph Evaluation. Am J Orthod Dentofacial Orthop. 2022 Dec;162(6):861-869. doi: 10.1016/j.ajodo.2021.07.023. Epub 2022 Sep 11. PMID: 36100480.

Tasca, A., Astleford, K. Blixt, N. Jensen, E. Gopalakrishnan, R., Mansky, K., 2018. SMAD 1/5 Signaling in Osteoclasts Regulates Bone Formation Via Coupling Factors. PLos One. 2018 Sep; 13(9): e0203404

Tasca, A., Astleford, K., Lederman, A., Jensen, E., Lee, B., Gopalakrishnan, R., Mansky, K., 2017. Regulation of Osteoclast Differentiation by Myosin X. Scientific Reports 7, Article number:7603

Tasca, A., Stemig, M., Broege, A., Huang, B., Davydova, J., Zwijsen, A., Umans, L., Jensen, E., Gopalakrishnan, R., and Mansky, K.C. 2015. Smad 1/5 and Smad 4 Expression Are Important for Osteoclast Differentiation. Journal of Cellular Biochemistry. 2015 Jul; 116(7): 1350-60.