Amy Tasca, DDS, PhD

Assistant Professor
Amy Tasca, DDS, PhD


Office Phone
Office Address

6-320 Moos Tower 515 Delaware St SE
Minneapolis, MN 55455
United States

Department of Developmental and Surgical Sciences,
Division of Orthodontics


Assistant Professor
Robert J. Isaacson Chair in Orthodontics


PhD, University of Minnesota
Major: Oral Biology

DDS, University of Missouri - Kansas City
Major: Dentistry

BA, University of Missouri - Kansas City
Major: Biology


Residency Orthodontics, University of Minnesota

Licensures and Certifications

Certificate Orthodontics, University of Minnesota
Orthodontics - College of Diplomates of the American Board of Orthodontics

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Dr. Tasca, originally from Winona, Minnesota, completed a six-year BA/DDS program at the University of Missouri Kansas City. After graduation, she practiced general dentistry in Breckenridge, Colorado and completed a teaching fellowship in Oral Surgery at UMKC. In 2012, Dr. Tasca returned to Minnesota to begin work on her PhD in conjunction with her Certificate in Orthodontics. At the completion of her residency program, she joined the University of Minnesota’s Division of Orthodontics as a full-time faculty member.

Research interests

Bone biology-Osteoclast differentiation

Clinical Cleft and Craniofacial care

Grants and Patents

Proposal: Comparison of Fixed Appliance Patients versus Clear Aligner( Invisalign) Patients for Oral Hygiene , Decalcifications and Comfort Scores
Role: Principal Investigator
Sponsoring Organization: Align
Date: September 2022

Proposal: Characterization of Mandibular Osteoclast Progenitors during Physiological and Bone Healing
Role: Co-Investigator
PI: Kim Mansky. Co-I: Elizabeth Bradley and Rachel Uppgaard
Sponsoring Organization: Osteoscience Foundation
Date: 01/01/2022-12/31/2024

Proposal: Where you originate from matters; A Comparison of Jaw and Long Bone
Osteoclast Precursors Using Single Cell Analysis
Role: Principal Investigator
Date: June 2022

NIH F32DE024679
The Role of Myosin X in BMPs Promotion of Smad1/5 in Osteoclast Formation and Function
Role: Primary Invsetigator
Sponsor: K. Mansky and R. Gopalakrishnan
Sponsoring Organization: NIH
Date: 5/2014-4/2016  


Nordeen KA, Kharouf JG, Mabry TR, Dahlke WO, Beiraghi S, Tasca AW. Radiographic Evaluation of Permanent Second Molar Substitution After Extraction of Permanent First Molar: Identifying Predictors for Spontaneous Space Closure. Pediatr Dent. 2022 Mar 15;44(2):123-130. PMID: 35484777.

Grünheid T, Tasca AW, Kanyusik JS, Walters SA, Larson BE. Assessment of orthodontic treatment efficacy of Clarity Aligners using the Peer Assessment Rating index and the American Board of Orthodontics Cast-Radiograph Evaluation. Am J Orthod Dentofacial Orthop. 2022 Dec;162(6):861-869. doi: 10.1016/j.ajodo.2021.07.023. Epub 2022 Sep 11. PMID: 36100480.

Tasca, A., Astleford, K. Blixt, N. Jensen, E. Gopalakrishnan, R., Mansky, K., 2018. SMAD 1/5 Signaling in Osteoclasts Regulates Bone Formation Via Coupling Factors. PLos One. 2018 Sep; 13(9): e0203404

Tasca, A., Astleford, K., Lederman, A., Jensen, E., Lee, B., Gopalakrishnan, R., Mansky, K., 2017. Regulation of Osteoclast Differentiation by Myosin X. Scientific Reports 7, Article number:7603

Tasca, A., Stemig, M., Broege, A., Huang, B., Davydova, J., Zwijsen, A., Umans, L., Jensen, E., Gopalakrishnan, R., and Mansky, K.C. 2015. Smad 1/5 and Smad 4 Expression Are Important for Osteoclast Differentiation. Journal of Cellular Biochemistry. 2015 Jul; 116(7): 1350-60.