Eric Jensen, PhD

Assistant Professor
Eric Jensen, PhD

Contact

Office Phone
Office Address

16-108B Moos Tower 515 Delaware St SE
Minneapolis, MN 55455
United States

Affiliations:
Department of Diagnostic and Biological Sciences,
Division of Oral and Maxillofacial Pathology

Titles

Assistant Professor

Education

PhD, University of Colorado
Major: Molecular, Cellular & Developmental Biology

BA, Cum laude, Saint Olaf College
Major: Biology

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Biography

Research Summary

My major interests are in understanding transcriptional gene regulatory mechanisms and signal transduction pathways that contribute to bone health and disease.

Transcriptional Regulation of Osteoblasts by HDAC7 and Runx2

Osteoblasts are the cells responsible for building new bone. There is great need in many orthopedic and dental conditions for new therapies to enhance bone growth and regeneration by osteoblasts. Formation of osteoblasts from mesenchymal stem cells involves Runx2, a transcription factor often called the master regulator of osteoblasts. Runx2 binds to the promoters of numerous target genes and can either activate or repress expression of these targets. I showed that Runx2 represses gene expression by recruiting Histone Deacetylase 7 to its targets. Loss of HDAC7 enhances osteoblast formation in cell culture suggesting that the Runx2-HDAC7 interaction might be a novel target to enhance bone growth. I then found that Bone Morphogenetic Protein signaling activates PKD to disrupt Runx2-HDAC7 interaction. Current projects in my lab include characterizing the effect of osteoblast-specific deletion of HDAC7 in mice, and investigating other partners and targets of HDAC7 in osteoblasts.

Regulation of Osteoclasts by HDACs and BMPs

Bone is broken down or resorbed by specialized multiucleated cells called osteoclasts. While this is an important part of normal bone maintenance and repair of damaged bone, excessive osteoclast activity leads to destructive bone loss in many cancers, arthritis, and periodontal disease and can contribute to loosening or failure of dental or orthopedic implants. Consequently there is a need to better understand the factors that regulate osteoclast formation and activity.

The transcription factor MITF is recruited at an early stage of osteoclast formation to the promoters of genes necessary for their differentiation but expression of these genes remains off until cells receive additional signals. I began a collaboration with Dr. Kim Mansky in which we used cell culture models to find that Histone Deacetylase 7 binds to MITF and represses transcription of osteoclast genes. Binding of HDAC7 to MITF is disrupted by the RANK Ligand cytokine, allowing gene expression and differentiation to proceed. We are following up on these studies to identify and understand other targets of HDAC7 in osteoclasts and how they are regulated.

Another collaborative project in my lab has been studying how BMP signaling regulates osteoclasts. BMPs are used clinically to promote bone growth and healing by osteoblasts. Working with Drs. Raj Gopalakrishnan, Kim Mansky and Anna Petryk, our group found that BMPs can also act directly on osteoclasts to increase bone resorption. This effect may contribute to destabilization or failure of bone regeneration protocols. We are currently using a variety of in vivo and in vitro models to determine the signal transduction pathways used by BMPs in osteoclasts.
 

Fellowships, Residencies, and Visiting Engagements

Postdoctoral Fellow, Fellowship
UMN School of Dentistry
Minneapolis, Minnesota, United States

Postdoctoral Fellow, Fellowship
UMN Masonic Cancer Center
Minneapolis, Minnesota, United States

Summer Undergraduate Research Associate, Other
Eppley Cancer Center
Omaha, Nebraska

Undergraduate Research Associate, Other
Oak Ridge National Laboratory
Oak Ridge, Tennessee

Honors and Recognition

National Merit Scholar

Professional Memberships

American Society for Bone & Mineral Research
 

Publications

Selected Publications

Leightner, A. C., Mello Guimaraes Meyers, C., Evans, M. D., Mansky, K. C., Gopalakrishnan, R., Jensen, E. D., 2020. Regulation of Osteoclast Differentiation at Multiple Stages by Protein Kinase D Family Kinases.. International journal of molecular sciences, 21 (3):
doi: https://doi.org/10.3390/ijms21031056 PubMed ID: 32033440.

Huntley, R., Jensen, E., Gopalakrishnan, R., Mansky, K. C., 2019. Bone morphogenetic proteins: Their role in regulating osteoclast differentiation.. Bone reports, 10 100207.
doi: https://doi.org/10.1016/j.bonr.2019.100207 PubMed ID: 31193008.

Tasca, A., Astleford, K., Blixt, N. C., Jensen, E. D., Gopalakrishnan, R., Mansky, K. C., 2018. SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors.. PloS one, 13 (9): e0203404.
doi: https://doi.org/10.1371/journal.pone.0203404 PubMed ID: 30188920.

Aukes, K., Forsman, C., Brady, N. J., Astleford, K., Blixt, N., Sachdev, D., Jensen, E. D., Mansky, K. C., Schwertfeger, K. L., 2017. Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions.. PloS one, 12 (10): e0185736.
doi: https://doi.org/10.1371/journal.pone.0185736 PubMed ID: 28968431.

Blixt, N. C., Faulkner, B. K., Astleford, K., Lelich, R., Schering, J., Spencer, E., Gopalakrishnan, R., Jensen, E. D., Mansky, K. C., 2017. Class II and IV HDACs function as inhibitors of osteoclast differentiation.. PloS one, 12 (9): e0185441.
doi: https://doi.org/10.1371/journal.pone.0185441 PubMed ID: 28953929.

Tasca, A., Astleford, K., Lederman, A., Jensen, E. D., Lee, B. S., Gopalakrishnan, R., Mansky, K. C., 2017. Regulation of Osteoclast Differentiation by Myosin X.. Scientific reports, 7 (1): 7603.
doi: https://doi.org/10.1038/s41598-017-07855-9 PubMed ID: 28790434.

Huntley, R., Davydova, J., Petryk, A., Billington, Jr, C. J., Jensen, E. D., Mansky, K. C., Gopalakrishnan, R., 2015. The Function of Twisted Gastrulation in Regulating Osteoclast Differentiation is Dependent on BMP Binding.. Journal of cellular biochemistry, 116 (10): 2239-46.
doi: https://doi.org/10.1002/jcb.25174 PubMed ID: 25808976.

Tasca, A., Stemig, M., Broege, A., Huang, B., Davydova, J., Zwijsen, A., Umans, L., Jensen, E. D., Gopalakrishnan, R., Mansky, K. C., 2015. Smad1/5 and Smad4 expression are important for osteoclast differentiation.. Journal of cellular biochemistry, 116 (7): 1350-60.
doi: https://doi.org/10.1002/jcb.25092 PubMed ID: 25711193.

Stemig, M., Astelford, K., Emery, A., Cho, J. J., Allen, B., Huang, T. H., Gopalakrishnan, R., Mansky, K. C., Jensen, E. D., 2015. Deletion of histone deacetylase 7 in osteoclasts decreases bone mass in mice by interactions with MITF.. PloS one, 10 (4): e0123843.
doi: https://doi.org/10.1371/journal.pone.0123843 PubMed ID: 25875108.

Li , Y., Chen, X., Ribeiro, A. J., Jensen, E. D., Holmberg, K. V., Rodriguez-Cabello, J. C., Aparicio, C., 2014. Hybrid nanotopographical surfaces obtained by biomimetic mineralization of statherin-inspired elastin-like recombinamers.. Advanced healthcare materials, 3 (10): 1638-47.
doi: https://doi.org/10.1002/adhm.201400015 PubMed ID: 24700504.

Broege, A., Pham, L., Jensen, E. D., Emery, A., Huang, T. H., Stemig, M., Beppu, H., Petryk, A., O'Connor, M., Mansky, K., Gopalakrishnan, R., 2013. Bone morphogenetic proteins signal via SMAD and mitogen-activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis.. The Journal of biological chemistry, 288 (52): 37230-40.
doi: https://doi.org/10.1074/jbc.M113.496950 PubMed ID: 24235143.

Mansky, K. C., Jensen, E. D., Davidova, J., Yamamoto, M., Gopalakrishnan, R., 2013. Protein kinase D promotes in vitro osteoclast differentiation and fusion.. The Journal of biological chemistry, 288 (14): 9826-34.
doi: https://doi.org/10.1074/jbc.M112.444133 PubMed ID: 23430742.

Basi, D. L., Hughes, P. J., Thumbigere-Math, V., Sabino, M., Mariash, A., Lunos, S. A., Jensen, E., Gopalakrishnan, R., 2011. Matrix metalloproteinase-9 expression in alveolar extraction sockets of Zoledronic acid-treated rats.. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 69 (11): 2698-707.
doi: https://doi.org/10.1016/j.joms.2011.02.065 PubMed ID: 21752506.

Zhang, H., Pan, Y., Zheng, L., Choe, C., Lindgren, B., Jensen, E. D., Westendorf, J. J., Cheng, L., Huang, H., 2011. FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion.. Cancer research, 71 (9): 3257-67.
doi: https://doi.org/10.1158/0008-5472.CAN-10-2603 PubMed ID: 21505104.

Pham, L., Kaiser, B., Romsa, A., Schwarz, T., Gopalakrishnan, R., Jensen, E. D., Mansky, K. C., 2011. HDAC3 and HDAC7 have opposite effects on osteoclast differentiation.. The Journal of biological chemistry, 286 (14): 12056-65.
doi: https://doi.org/10.1074/jbc.M110.216853 PubMed ID: 21324898.

Pham, L., Beyer, K., Jensen, E. D., Rodriguez, J. S., Davydova, J., Yamamoto, M., Petryk, A., Gopalakrishnan, R., Mansky, K. C., 2011. Bone morphogenetic protein 2 signaling in osteoclasts is negatively regulated by the BMP antagonist, twisted gastrulation.. Journal of cellular biochemistry, 112 (3): 793-803.
doi: https://doi.org/10.1002/jcb.23003 PubMed ID: 21328453.

Schwarz, T., Sohn, C., Kaiser, B., Jensen, E. D., Mansky, K. C., 2010. The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts.. Journal of cellular biochemistry, 109 (5): 967-74.
doi: https://doi.org/10.1002/jcb.22475 PubMed ID: 20058232.
Jensen, E. D., Pham, L., Billington, Jr, C. J., Espe, K., Carlson, A. E., Westendorf, J. J., Petryk, A., Gopalakrishnan, R., Mansky, K., 2010. Bone morphogenic protein 2 directly enhances differentiation of murine osteoclast precursors.. Journal of cellular biochemistry, 109 (4): 672-82.
doi: https://doi.org/10.1002/jcb.22462 PubMed ID: 20039313.

Jensen, E. D., Gopalakrishnan, R., Westendorf, J. J., 2010. Regulation of gene expression in osteoblasts.. BioFactors (Oxford, England), 36 (1): 25-32.
doi: https://doi.org/10.1002/biof.72 PubMed ID: 20087883.

Sotillo Rodriguez, J. E., Mansky, K. C., Jensen, E. D., Carlson, A. E., Schwarz, T., Pham, L., MacKenzie, B., Prasad, H., Rohrer, M. D., Petryk, A., Gopalakrishnan, R., 2009. Enhanced osteoclastogenesis causes osteopenia in twisted gastrulation-deficient mice through increased BMP signaling.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 24 (11): 1917-26.
doi: https://doi.org/10.1359/jbmr.090507 PubMed ID: 19419314.

Hoeppner, L. H., Secreto, F., Jensen, E. D., Li , X., Kahler, R. A., Westendorf, J. J., 2009. Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation.. Journal of cellular physiology, 221 (2): 480-9.
doi: https://doi.org/10.1002/jcp.21879 PubMed ID: 19650108.

Li , X., Hoeppner, L. H., Jensen, E. D., Gopalakrishnan, R., Westendorf, J. J., 2009. Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors.. Journal of cellular biochemistry, 108 (2): 378-87.
doi: https://doi.org/10.1002/jcb.22263 PubMed ID: 19585539.

Suttamanatwong, S., Jensen, E. D., Schilling, J., Franceschi, R. T., Carlson, A. E., Mansky, K. C., Gopalakrishnan, R., 2009. Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone.. Journal of cellular biochemistry, 107 (2): 284-92.
doi: https://doi.org/10.1002/jcb.22124 PubMed ID: 19306294.

Jensen, E. D., Gopalakrishnan, R., Westendorf, J. J., 2009. Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2.. The Journal of biological chemistry, 284 (4): 2225-34.
doi: https://doi.org/10.1074/jbc.M800586200 PubMed ID: 19029091.

Schlosser, G., Awtry, T., Brugmann, S. A., Jensen, E. D., Neilson, K., Ruan, G., Stammler, A., Voelker, D., Yan, B., Zhang, C., Klymkowsky, M. W., Moody, S. A., 2008. Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion.. Developmental biology, 320 (1): 199-214.
doi: https://doi.org/10.1016/j.ydbio.2008.05.523 PubMed ID: 18571637.

Kahler, R. A., Yingst, S. M., Hoeppner, L. H., Jensen, E. D., Krawczak, D., Oxford, J. T., Westendorf, J. J., 2008. Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation.. Matrix biology : journal of the International Society for Matrix Biology, 27 (4): 330-8.
doi: https://doi.org/10.1016/j.matbio.2008.01.002 PubMed ID: 18280717.

Jensen, E. D., Niu, L., Caretti, G., Nicol, S. M., Teplyuk, N., Stein, G. S., Sartorelli, V., van Wijnen, A. J., Fuller-Pace, F. V., Westendorf, J. J., 2008. p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation.. Journal of cellular biochemistry, 103 (5): 1438-51.
doi: https://doi.org/10.1002/jcb.21526 PubMed ID: 17960593.

Jensen, E. D., Schroeder, T. M., Bailey, J., Gopalakrishnan, R., Westendorf, J. J., 2008. Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 23 (3): 361-72.
doi: https://doi.org/10.1359/jbmr.071104 PubMed ID: 17997710.

Jensen, E. D., Nair, A. K., Westendorf, J. J., 2007. Histone deacetylase co-repressor complex control of Runx2 and bone formation.. Critical reviews in eukaryotic gene expression, 17 (3): 187-96.
doi: https://doi.org/10.1615/critreveukargeneexpr.v17.i3.20 PubMed ID: 17725488.

Schroeder, T. M., Jensen, E. D., Westendorf, J. J., 2005. Runx2: a master organizer of gene transcription in developing and maturing osteoblasts.. Birth defects research. Part C, Embryo today : reviews, 75 (3): 213-25.
doi: https://doi.org/10.1002/bdrc.20043 PubMed ID: 16187316.

Zhang, C., Basta, T., Jensen, E. D., Klymkowsky, M. W., 2003. The beta-catenin/VegT-regulated early zygotic gene Xnr5 is a direct target of SOX3 regulation.. Development (Cambridge, England), 130 (23): 5609-24.
doi: https://doi.org/10.1242/dev.00798 PubMed ID: 14522872.

Presentations

Selected Presentations

Burciaga, S., Campbell, E., Kazemi, P., Jensen, E. D. "Regulation of Osteoclast Formation and Bone Resorption by Protein Kinase D2 and Protein Kinase D3", Bones & Teeth, Gordon Research Conferences, Galveston, Texas, January 01, 2020.

Jensen, E. D. "Regulation of Osteoclast Formation & Function by Protein Kinase D", UMN School of Dentistry Research Seminar Series, January 01, 2020.

Meyers, C. G., Mansky, K., Jensen, E. D. "Regulation of Osteoclastogenesis by Protein Kinase D2 and Protein Kinase D3", Annual Meeting, American Society for Bone & Mineral Research, Quebec, Canada. January 01, 2018.

Jensen, E. D. "Novel Regulators of Osteoclast Formation & Function", Dean's Research Day, UMN School of Dentistry, Minneapolis, Minnesota, January 01, 2018.

Faulkner, B., Blixt, N., Gopalakrishnan, R., Jensen, E. D., Mansky, K. "HDAC4-ERK Crosstalk Regulates Osteoclast Function", Annual Meeting, American Society for Bone & Mineral Research, Quebec, Canada. January 01, 2018.

Leightner, A. C., Mansky, K., Gopalakrishnan, R., Jensen, E. D. "Protein Kinase D2 Regulation of the Actin Cytoskeleton During Osteoclast Differentiation", Annual Meeting, American Society for Bone & Mineral Research, Seattle, Washington, January 01, 2017.

Godejohn, B., Stark, M., Faulkner, B., Astleford, K., Blixt, N., Gopalakrishnan, R., Jensen, E. D., Mansky, K. "Subcellular Localization of HDACs During Osteoclast Differentiation", Annual Meeting, IADR/AADR/CADR, San Francisco, California, January 01, 2017.

Blixt, N., Gopalakrishnan, R., Jensen, E. D., Mansky, K. "Amino Terminus of HDAC7 is Sufficient to Inhibit Osteoclast Differentiation", Annual Meeting, American Society for Bone & Mineral Research, Atlanta, Georgia, January 01, 2017.

Blixt, N., Gopalakrishnan, R., Mansky, K., Jensen, E. D. "PU.1 and HDAC7 Interact to Regulate Osteoclast Differentiation", Annual Meeting, American Society for Bone & Mineral Research, Seattle, Washington, January 01, 2015.

Tasca, A., Stemig, M., Broege, A., Jensen, E. D., Gopalakrishnan, R., Mansky, K. "BMP/SMAD Pathway Regulates the Formation and Resorptive Activity of Osteoclasts", Annual Meeting, American Association for Dental Research, Boston, Massachusetts, January 01, 2015.

Jensen, E. D. "Regulation of Skeletal Dynamics by Histone Deacetylase 7", Comparative Oncology Seminar Series, UMN College of Veterinary Medicine, January 01, 2015.

Huntley, R., Jensen, E. D., Mansky, K., Gopalakrishnan, R. "Cooperative Function of CV-2 and TWSG1 in Regulating Osteoclastogenesis", Annual Meeting, American Association for Dental Research, Boston, Massachusetts, January 01, 2015.

Stemig, M., Huntley, R., Petryk, A., Mansky, K., Gopalakrishnan, R., Jensen, E. D. "Twisted gastrulation-deficient Osteoclast Precursors are Hypersensitive to RANKL and M-CSF due to Changes in RANK and c-Fms Expression", Annual Meeting, American Society for Bone & Mineral Research, Seattle, Washington, January 01, 2015.

Tasca, A., Stemig, M., Broege, A., Huang, B., Jensen, E. D., Mansky, K., Gopalakrishnan, R. "BMP Responsive SMADs are Required for Osteoclast Differentiation", Annual Meeting, American Society for Bone & Mineral Research, Houston, Texas, January 01, 2014.

Jensen, E. D., Mansky, K., Gopalakrishnan, R. "Canonical and non-canonical BMP Signaling Directly Regulates Osteoclasts", Bones & Teeth, Gordon Research Conferences, Galveston, Texas, January 01, 2014.

Mansky, K., Jensen, E. D., Gopalakrishnan, R. "MITF/PU.1 is Negatively Regulated by HDAC7 during Osteoclast Differentiation", Bones & Teeth, Gordon Research Conferences, Galveston, Texas, January 01, 2014.

Stemig, M., Astleford, K., Emery, A., Huang, T., Cho, J., Gopalakrishnan, R., Mansky, K., Jensen, E. D. "Loss of HDAC7 in Osteoclasts Decreases Bone Mass Through Interactions with MITF and PU.1", Annual Meeting, American Society for Bone & Mineral Research, Houston, Texas, January 01, 2014.

Jensen, E. D. "There & Back Again", UMN Musculoskeletal Biology Training Program Research Retreat, Saint Paul, Minnesota, January 01, 2014.

Jensen, E. D. "HDAC7: evolution, proliferation, metastasis, differentiation and occasional mutation of a research project", UMN Graduate Program in Oral Biology Seminar Series, Minneapolis, Minnesota, January 01, 2013.

Jensen, E. D. "Regulation of Osteoclast Differentiation by Histone Deacetylase 7", UMN School of Dentistry Research Retreat, Saint Paul, Minnesota, January 01, 2013.

Broege, A., Huntley, R., Shaker, Z., Jensen, E. D., Mansky, K., Gopalakrishnan, R. "Downstream Effects of BMP Signaling in Osteoclasts: BMPs Induce MKP1 Activity and NFATc1 Nuclear Localization", Annual Meeting, American Society for Bone & Mineral Research, Baltimore, Maryland, January 01, 2013.

Broege, A., Jensen, E. D., Shaker, Z., Mansky, K., Gopalakrishnan, R. "Evaluating BMP Signaling During Osteoclast Differentiation", Annual Meeting, American Association for Dental Research, Seattle, Washington, January 01, 2013.

Pham, L., Broege, A., Stemig, M., O'Connor, M. B., Petryk, A., Jensen, E. D., Gopalakrishnan, R., Mansky, K. "The in vivo Role of BMPRII in Murine Osteoclasts", Annual Meeting, American Association for Dental Research, Seattle, Washington, January 01, 2013.

Huntley, R., Pham, L., Broege, A., Petryk, A., Jensen, E. D., Mansky, K., Gopalakrishnan, R. "Twisted gastrulation-deficient Osteoclasts are Hypersensitive to RANKL and M-CSF", Annual Meeting, American Association for Dental Research, Seattle, Washington, January 01, 2013.

Huntley, R., Gopalakrishnan, R., Billington, C., Pham, L., Jensen, E. D., Broege, A., Petryk, A., Mansky, K. "BMP-Binding is Essential for Inhibitor Effects of Twisted Gastrulation on Osteoclast Differentiation", Annual Meeting, American Society for Bone & Mineral Research, Baltimore, Maryland, January 01, 2013.

Jensen, E. D., Pham, L., Emery, A., Stemig, M., Gopalakrishnan, R., Mansky, K. "HDAC7 Regulates Osteoclastogenesis by Repressing MITF Activity", Annual Meeting, American Society for Bone & Mineral Research, Minneapolis, Minnesota, January 01, 2012.

Broege, A., Pham, L., Emery, A., Stemig, M., O'Connor, M. B., Petryk, A., Jensen, E. D., Mansky, K., Gopalakrishnan, R. "Canonical and Non-canonical BMP Signaling Pathways Regulate Osteoclastogenesis", Annual Meeting, American Society for Bone & Mineral Research, Minneapolis, Minnesota, January 01, 2012.

Jensen, E. D. "Regulation of Osteoclast Formation by Histone Deacetylases", Schachtele Memorial Symposium in Oral Biology, UMN Graduate Progam in Oral Biology, Minneapolis, Minnesota, January 01, 2011.

Jensen, E. D., Pham, L., Gopalakrishnan, R., Mansky, K. "Protein Kinase D Regulates Osteoclast Differentiation", Annual Meeting, American Society for Bone & Mineral Research, San Diego, California, January 01, 2011.

Jensen, E. D. "Regulation of Bone by Histone Deacetylase 7", UMN Musculoskeletal Biology Training Program Research Retreat, Minneapolis, Minnesota, January 01, 2011.

Jensen, E. D. "Regulation of Bone by Histone Deacetylase 7", UMN Developmental Biology Club Seminar Series, January 01, 2011.

Nederlow, D., Aparicio - Badenas, C. J., Jensen, E. D., Brooks, M. A., Gopalakrishnan, R., Rodriguez-Cabello, C., Salvagni, E., Planell, J. A. "Osteoblast Response on Titanium Biofunctionalized with Elastin-like Recombinant Biopolymers", Annual Meeting, American Association for Dental Research, Washington DC, January 01, 2010.

Jensen, E. D., Aparicio - Badenas, C. J., Nedrelow, D., Li, Y., Salvagni, E., Rodriguez-Cabello, C., Planell, J. "Cell Response on Titanium Coated with Multifunctional Recombinant Biopolymers", Annual Meeting, International Association for Dental Research, Barcelona, Spain. January 01, 2010.

Pham, L., Jensen, E. D., Gopalakrishnan, R., Mansky, K. "Twisted gastrulation, a Negative Regulator of BMP Signaling in Osteoclasts", Annual Meeting, American Society for Bone & Mineral Research, Toronto, Canada. January 01, 2010.

Jensen, E. D., Pham, L., Mansky, K. "HDAC3 and HDAC7 Have Opposite Effects on Osteoclast Differentiation", Annual Meeting, American Society for Bone & Mineral Research, Toonto, Canada. January 01, 2010.

Jensen, E. D., Khamannivong, A., Westerndorf, J., Mansky, K., Gopalakrishnan, R. "HDAC7 Represses Proliferation and Differentiation of Osteoblasts", Annual Meeting, American Society for Bone & Mineral Research, Toronto, Canada. January 01, 2010.

Pham, L., Jensen, E. D., Beyer, K., Billington, C., Rodriguez Sotillo, J., Davydova, J., Yamamoto, M., Petryk, A., Mansky, K., Gopalakrishnan, R. "Anti-resorptive Activity of Twisted-gastrulation, a regulator of BMP Signaling in Osteoclasts", Annual Meeting, American Association for Dental Research, Washington DC, January 01, 2010.

Jensen, E. D., A. K., Westendorf, J., Mansky, K., Gopalakrishnan, R. "HDAC7 Inhibits Proliferation and Differentiation of Osteoblasts", Skull & Bones: The Intersection of Craniofacial Development adn Skeletal Biology, UMN Musculoskeletal Biology Tranining Program & MinnCrest Training Program, January 01, 2010.

Jensen, E. D., L., Espe, K., Emery, A., Westendorf, J., Petryk, A., Gopalakrishnan, R., Mansky, K. "Bone Morphogenic Protein Signaling Directly Enhances Differentiation of Murine Osteoclast Precursors", Workshop on the Roles of Twisted gastrulaion in Embryonic and Postnatal Development, Minneapolis, Minnesota, January 01, 2009.

Jensen, E. D., Pham, L., Billongton, C., Espe, K., Emery, A., Westendorf, J., Petryk, A., Gopalakrishnan, R., Mansky, K. "Bone Morphogenetic Protein signaling Directly Enhances Differentiation of Murine Osteoclast Precursors", Annual Meeting, American Society for Bone & Mineral Research, Denver, Colorado, January 01, 2009.

Sotillo Rodriguez, J., Mansky, K., Carlson, A., Schwarz, T., MacKenzie, B., Jensen, E. D., Petryk, A., Gopalakrishnan, R. "Enhanced Osteoclastogenesis Causes Osteopenia in Twisted gastrulation -deficient mice", Annual Meeting, American Society for Bone & Mineral Research, Montreal, Canada. January 01, 2008.

Jensen, E. D., Gopalakrishnan, R., Westendorf, J. "Bone Morphogenic Protein 2 Activates Protein Kinase D to Regulate HDAC7 Localization and Repression of Runx2", Annual Meeting, American Society for Bone & Mineral Research, Montreal, Canada. January 01, 2008.

Jensen, E. D., Li, X., Schroeder, T., Bailey, J., Gopalakrishnan, R., Westendorf, J. "HDAC7 Represses Runx2 Activity During Osteoblast Differentiation", Bones & Teeth, Gordon Research Conferences, Biddeford, Maine, January 01, 2007.
L. H., Jensen, E. D., Westendorf, J. "A Lymphoid Enhancer Binding Factor (LEF)-1 Isoform Regulates Osteoblast Maturation", Annual Meeting, American Society for Bone & Mineral Research, Honolulu, Hawaii, January 01, 2007.

Jensen, E. D., Nair, A., Schroeder, T., Westendorf, J. "Regulation of Osteoblast Gene Expresion by HDAC7-mediated Repression of Runx2 and HDAC inhibitors", Annual Meeting, American Society for Bone & Mineral Research, Philadelphia, Pennsylvania, January 01, 2006.

Jensen, E. D., Li, X., Schroeder, T., Westendorf, J. "Histone Deacetylase 7 Interacts with Runx2 and Attenuates Runx2-Dependent Transactivation", Nuclear Structure and Cancer, FASEB, Saxtons River, Vermont, January 01, 2005.

Jensen, E. D., Schroeder, T., Li, X., Westendorf, J. "Multiple Histone Deacetylases and Histone Deacetylase Inhibitors Influence Runx2 Activities and Osteoblast Maturation", Annual Meeting, American Society for Bone & Mineral Research, Nashville, Tennessee, January 01, 2005.

Jensen, E. D., Fawcett, S., Bailey, A., Klymkowsky, M. W. "Regulation of Neural and Neural Crest Patterning by beta-Catenin and SOXs", Annual Meeting, American Society for Cell Biology, San Francisco, California, January 01, 2002.

Meyers, M., Dawson, S., Jensen, E. D., Parkhurst, S. M. "Identification of Maternally Acting Genes using wimp", Annual Meeting, Genetics Society of America, San Francisco, California, January 01, 1996.

Grants and Patents

Selected Grants

Award: Role of HDAC7 in Osteoclast Differentiation
Principal Investigator: Mansky, Kim
Sponsoring Organization: NIH NIAMS NATL INST OF ARTHRIT
Award Dates: 2013 - 2016

Award: Function of HDAC7 in Osteoblasts
Principal Investigator: Jensen, Eric David
Sponsoring Organization: NIH NIDCR NATL INST OF DENTAL
Award Dates: 2010 - 2012